IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

Fluid and HCO(3)(–) secretion are fundamental functions of epithelia and determine bodily fluid volume and ionic composition, among other things. Secretion of ductal fluid and HCO(3)(–) in secretory glands is fueled by Na(+)/HCO(3)(–) cotransport mediated by basolateral solute carrier family 4 membe...

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Main Authors: Yang, Dongki, Li, Qin, So, Insuk, Huang, Chou-Long, Ando, Hideaki, Mizutani, Akihiro, Seki, George, Mikoshiba, Katsuhiko, Thomas, Philip J., Muallem, Shmuel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049373/
https://ncbi.nlm.nih.gov/pubmed/21317537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43475
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