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IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

Fluid and HCO(3)(–) secretion are fundamental functions of epithelia and determine bodily fluid volume and ionic composition, among other things. Secretion of ductal fluid and HCO(3)(–) in secretory glands is fueled by Na(+)/HCO(3)(–) cotransport mediated by basolateral solute carrier family 4 membe...

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Detalhes bibliográficos
Main Authors: Yang, Dongki, Li, Qin, So, Insuk, Huang, Chou-Long, Ando, Hideaki, Mizutani, Akihiro, Seki, George, Mikoshiba, Katsuhiko, Thomas, Philip J., Muallem, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049373/
https://ncbi.nlm.nih.gov/pubmed/21317537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43475
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