IRBIT coordinates epithelial fluid and HCO(3)(–) secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct

Fluid and HCO(3)(–) secretion are vital functions of secretory epithelia. In most epithelia, this entails HCO(3)(–) entry at the basolateral membrane, mediated by the Na(+)-HCO(3)(–) cotransporter, pNBC1, and exit at the luminal membrane, mediated by a CFTR-SLC26 transporters complex. Here we report...

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Detalhes bibliográficos
Main Authors: Yang, Dongki, Shcheynikov, Nikolay, Zeng, Weizhong, Ohana, Ehud, So, Insuk, Ando, Hideaki, Mizutani, Akihiro, Mikoshiba, Katsuhiko, Muallem, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613461/
https://ncbi.nlm.nih.gov/pubmed/19033647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36983
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