IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na(+)/HCO(3)(−) cotransporter 1 (pNBC1)

Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are IP(3)-gated Ca(2+) channels that are located on intracellular Ca(2+) stores. We previously identified an IP(3)R binding protein, termed IP(3)R binding protein released with IP(3) (IRBIT). Because IRBIT is released from IP(3)R by physiologi...

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Hauptverfasser: Shirakabe, Kyoko, Priori, Giuseppina, Yamada, Hideomi, Ando, Hideaki, Horita, Shoko, Fujita, Toshiro, Fujimoto, Ichiro, Mizutani, Akihiro, Seki, George, Mikoshiba, Katsuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480443/
https://ncbi.nlm.nih.gov/pubmed/16769890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602250103
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