Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders characterized by progressive muscle wasting and often premature death. The primary defect common to most MDs involves disruption of the dystrophin-glycoprotein complex (DGC). This leads to sarcolemmal instability and Ca(2+)...

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Main Authors: Goonasekera, Sanjeewa A., Lam, Chi K., Millay, Douglas P., Sargent, Michelle A., Hajjar, Roger J., Kranias, Evangelia G., Molkentin, Jeffery D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049367/
https://ncbi.nlm.nih.gov/pubmed/21285509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43844
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