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Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

Muscular dystrophy is a general term encompassing muscle disorders that cause weakness and wasting, typically leading to premature death. Membrane instability, as a result of a genetic disruption within the dystrophin-glycoprotein complex (DGC), is thought to induce myofiber degeneration, although t...

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Bibliografiske detaljer
Main Authors: Millay, Douglas P., Goonasekera, Sanjeewa A., Sargent, Michelle A., Maillet, Marjorie, Aronow, Bruce J., Molkentin, Jeffery D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776441/
https://ncbi.nlm.nih.gov/pubmed/19864620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906591106
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