Age-Dependent Effect of Myostatin Blockade on Disease Severity in a Murine Model of Limb-Girdle Muscular Dystrophy

Myostatin (MSTN) is a muscle-specific secreted peptide that functions to limit muscle growth through an autocrine regulatory feedback loop. Loss of MSTN activity in cattle, mice, and humans leads to a profound phenotype of muscle overgrowth, associated with more and larger fibers and enhanced regene...

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Main Authors: Parsons, Stephanie A., Millay, Douglas P., Sargent, Michelle A., McNally, Elizabeth M., Molkentin, Jeffery D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2006
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606625/
https://ncbi.nlm.nih.gov/pubmed/16723712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051316
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