Antitumor Agents 284. New Desmosdumotin B Analogues with Bicyclic B-ring as Cytotoxic and Antitubulin Agents

We previously reported that the biological activity of analogues of desmosdumotin B (1) was dramatically changed depending on the B-ring system. A naphthalene B-ring analogue 3 exerted potent in vitro activity against a diverse panel of human tumor cell lines with GI(50) values of 0.8–2.1 μM. In con...

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Main Authors: Nakagawa-Goto, Kyoko, Wu, Pei-Chi, Lai, Chin-Yu, Hamel, Ernest, Zhu, Hao, Zhang, Liying, Kozaka, Takashi, Ohkoshi, Emika, Goto, Masuo, Bastow, Kenneth F., Lee, Kuo-Hsiung
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048907/
https://ncbi.nlm.nih.gov/pubmed/21284385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1011947
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