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Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells
[Image: see text] We report a general strategy for creating protein kinases in mammalian cells that are poised for very rapid activation by light. By photoactivating a caged version of MEK1, we demonstrate the specific, rapid, and receptor independent activation of an artificial subnetwork within th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048767/ https://ncbi.nlm.nih.gov/pubmed/21271704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1109979 |
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