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Disruption of the Viral Polymerase Complex Assembly as a Novel Approach to Attenuate Influenza A Virus
To develop a novel attenuation strategy applicable to all influenza A viruses, we targeted the highly conserved protein-protein interaction of the viral polymerase subunits PA and PB1. We postulated that impaired binding between PA and PB1 would negatively affect trimeric polymerase complex formatio...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048726/ https://ncbi.nlm.nih.gov/pubmed/21183679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205534 |
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