Disruption of the Viral Polymerase Complex Assembly as a Novel Approach to Attenuate Influenza A Virus

To develop a novel attenuation strategy applicable to all influenza A viruses, we targeted the highly conserved protein-protein interaction of the viral polymerase subunits PA and PB1. We postulated that impaired binding between PA and PB1 would negatively affect trimeric polymerase complex formatio...

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Bibliografiska uppgifter
Huvudupphovsmän: Mänz, Benjamin, Götz, Veronika, Wunderlich, Kerstin, Eisel, Jessica, Kirchmair, Johannes, Stech, Jürgen, Stech, Olga, Chase, Geoffrey, Frank, Ronald, Schwemmle, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048726/
https://ncbi.nlm.nih.gov/pubmed/21183679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205534
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