Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase

The influenza A virus polymerase complex, consisting of the subunits PB1, PB2, and PA, represents a promising target for the development of new antiviral drugs. We have previously demonstrated the feasibility of targeting the protein-protein interaction domain between PA and PB1 using peptides deriv...

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Bibliographische Detailangaben
Hauptverfasser: Wunderlich, Kerstin, Juozapaitis, Mindaugas, Ranadheera, Charlene, Kessler, Ulrich, Martin, Arnold, Eisel, Jessica, Beutling, Ulrike, Frank, Ronald, Schwemmle, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028788/
https://ncbi.nlm.nih.gov/pubmed/21135188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01419-10
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