Adaptive Mutations in the Nuclear Export Protein of Human-Derived H5N1 Strains Facilitate a Polymerase Activity-Enhancing Conformation

The nuclear export protein (NEP) (NS2) of the highly pathogenic human-derived H5N1 strain A/Thailand/1(KAN-1)/2004 with the adaptive mutation M16I greatly enhances the polymerase activity in human cells in a concentration-dependent manner. While low NEP levels enhance the polymerase activity, high l...

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Autores principales: Reuther, Peter, Giese, Sebastian, Götz, Veronika, Kilb, Normann, Mänz, Benjamin, Brunotte, Linda, Schwemmle, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911765/
https://ncbi.nlm.nih.gov/pubmed/24155389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01495-13
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