Copper Promotes the Trafficking of the Amyloid Precursor Protein

Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases t...

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Detalhes bibliográficos
Main Authors: Acevedo, Karla M., Hung, Ya Hui, Dalziel, Andrew H., Li, Qiao-Xin, Laughton, Katrina, Wikhe, Krutika, Rembach, Alan, Roberts, Blaine, Masters, Colin L., Bush, Ashley I., Camakaris, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048711/
https://ncbi.nlm.nih.gov/pubmed/21177866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128512
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