Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics through the secretory pathway. We have previously reported that copper promotes a change in the cellular localization of APP. We now report...

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Detalhes bibliográficos
Main Authors: Acevedo, Karla M., Opazo, Carlos M., Norrish, David, Challis, Leesa M., Li, Qiao-Xin, White, Anthony R., Bush, Ashley I., Camakaris, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036242/
https://ncbi.nlm.nih.gov/pubmed/24610780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538710
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