PIASy Inhibits Virus-induced and Interferon-stimulated Transcription through Distinct Mechanisms

The protein inhibitor of activated STAT (PIAS) family proteins regulates innate immune responses by controlling transcription induced by Toll-like receptor, RIG-I-like receptor signaling, and JAK/STAT pathways. Here, we show that PIASy negatively regulates type I interferon (IFN) transcription. Viru...

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Bibliographische Detailangaben
Hauptverfasser: Kubota, Toru, Matsuoka, Mayumi, Xu, Songxiao, Otsuki, Noriyuki, Takeda, Makoto, Kato, Atsushi, Ozato, Keiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048703/
https://ncbi.nlm.nih.gov/pubmed/21199872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195255
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