Type I Interferon Induction in Dendritic Cells Requires IRF-8 That Effects the Feedback Phase of Transcription

Dendritic cells (DCs) produce type I interferons (IFNs) in greater amounts than other cells, but the mechanisms remain elusive. Here we studied the role of a transcription factor, IRF-8 in DC induction of type I IFNs. Upon NDV infection, bone marrow derived plasmacytoid and conventional DCs induced...

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Bibliographic Details
Main Authors: Tailor, Prafullakumar, Tamura, Tomohiko, Kong, Hee Jeong, Kubota, Toru, Kubota, Mayumi, Borghi, Paola, Gabriele, Lucia, Ozato, Keiko
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768351/
https://ncbi.nlm.nih.gov/pubmed/17702615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.06.009
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