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The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse

Among dendritic cell (DC) subsets, CD8α(+) DCs and plasmacytoid DCs (pDCs) produce high levels of IL12 and type I interferons (IFNs), respectively, and confer early innate immunity. Development of CD8α(+) DCs and pDCs requires the interferon regulatory factor 8 (IRF8). Recently, a spontaneous point...

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Bibliografske podrobnosti
Main Authors: Tailor, Prafullakumar, Tamura, Tomohiko, Morse, Herbert C., Ozato, Keiko
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234043/
https://ncbi.nlm.nih.gov/pubmed/18055870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-100750
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