Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production

Inhibitor of κB kinase ε (IKKε) and TANK binding kinase 1 (TBK1), so-called non-canonical IKKs or IKK-related kinases, are involved in the cellular innate immunity by inducing type I IFNs. Two kinases commonly phosphorylate transcription factors IRF3 and IRF7 in type I IFN production pathway. In con...

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Main Authors: Nakatsu, Yuichiro, Matsuoka, Mayumi, Chang, Tsung-Hsien, Otsuki, Noriyuki, Noda, Masahiro, Kimura, Hirokazu, Sakai, Kouji, Kato, Hiroshi, Takeda, Makoto, Kubota, Toru
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983252/
https://ncbi.nlm.nih.gov/pubmed/24722368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094999
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