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Endotoxin Tolerance Impairs IL-1 Receptor-Associated Kinase (IRAK) 4 and TGF-β-activated Kinase 1 Activation, K63-linked Polyubiquitination and Assembly of IRAK1, TNF Receptor-associated Factor 6, and IκB Kinase γ and Increases A20 Expression

Endotoxin tolerance reprograms Toll-like receptor 4 responses by impairing LPS-elicited production of pro-inflammatory cytokines without inhibiting expression of anti-inflammatory or anti-microbial mediators. In septic patients, Toll-like receptor tolerance is thought to underlie decreased pro-infla...

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Detalhes bibliográficos
Main Authors: Xiong, Yanbao, Qiu, Fu, Piao, Wenji, Song, Chang, Wahl, Larry M., Medvedev, Andrei E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048677/
https://ncbi.nlm.nih.gov/pubmed/21220427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182873
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