A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis

BACKGROUND: Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. During G1 and S and in cellular response to DNA damage, Cdc25A is targeted for d...

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Detalhes bibliográficos
Main Authors: Bahassi, El Mustapha, Yin, Moying, Robbins, Susan B, Li, Ya-Qin, Conrady, Deborah G, Yuan, Zhenyu, Kovall, Rhett A, Herr, Andrew B, Stambrook, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048473/
https://ncbi.nlm.nih.gov/pubmed/21310058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-6-4
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