A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis

<p>Abstract</p> <p>Background</p> <p>Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. During G1 and S and in ce...

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Main Authors: Kovall Rhett A, Yuan Zhenyu, Conrady Deborah G, Li Ya-Qin, Robbins Susan B, Yin Moying, Bahassi El Mustapha, Herr Andrew B, Stambrook Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2011-02-01
Colecção:Cell Division
Acesso em linha:http://www.celldiv.com/content/6/1/4
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