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Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias
The CHEK2 kinase (Chk2 in mouse) is a member of a DNA damage response pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the repair of dsDNA breaks by a recombination-mediated mechanism. There are numerous variants of the CHEK2 gene, at least one of which, CHEK2*1100d...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761365/ https://ncbi.nlm.nih.gov/pubmed/19805189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909237106 |
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