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Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures
Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X-ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical classes. Five...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048427/ https://ncbi.nlm.nih.gov/pubmed/21280133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.575 |
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