Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X-ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical classes. Five...

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Hlavní autoři: Kuglstatter, Andreas, Wong, April, Tsing, Stan, Lee, Simon W, Lou, Yan, Villaseñor, Armando G, Bradshaw, J Michael, Shaw, David, Barnett, Jim W, Browner, Michelle F
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048427/
https://ncbi.nlm.nih.gov/pubmed/21280133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.575
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