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Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes
Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. The lifespan of the active form of PAI-1 is modulated via interaction with the plasma protein, vitronectin, and various metal ions. These metal ions fall into two categories: Ty...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048421/ https://ncbi.nlm.nih.gov/pubmed/21280128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.567 |
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