Crystal Structure of Plasminogen Activator Inhibitor-1 in an Active Conformation with Normal Thermodynamic Stability

The serpin plasminogen activator inhibitor-1 (PAI-1) is a crucial regulator in fibrinolysis and tissue remodeling. PAI-1 has been associated with several pathological conditions and is a validated prognostic marker in human cancers. However, structural information about the native inhibitory form of...

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Main Authors: Jensen, Jan K., Thompson, Lawrence C., Bucci, Joel C., Nissen, Poul, Gettins, Peter G. W., Peterson, Cynthia B., Andreasen, Peter A., Morth, J. Preben
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191012/
https://ncbi.nlm.nih.gov/pubmed/21697084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236554
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