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Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes

Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. The lifespan of the active form of PAI-1 is modulated via interaction with the plasma protein, vitronectin, and various metal ions. These metal ions fall into two categories: Ty...

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Autori principali: Thompson, Lawrence C, Goswami, Sumit, Peterson, Cynthia B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048421/
https://ncbi.nlm.nih.gov/pubmed/21280128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.567
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