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Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition
Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. Under physiological conditions, half of the inhibitor transitions to a latent state within 1–2 h. The interaction between PAI-1 and the plasma protein vitronectin prolongs this...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048420/ https://ncbi.nlm.nih.gov/pubmed/21280127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.568 |
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