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Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition

Human plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor with a metastable active conformation. Under physiological conditions, half of the inhibitor transitions to a latent state within 1–2 h. The interaction between PAI-1 and the plasma protein vitronectin prolongs this...

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Main Authors: Thompson, Lawrence C, Goswami, Sumit, Ginsberg, David S, Day, Duane E, Verhamme, Ingrid M, Peterson, Cynthia B
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048420/
https://ncbi.nlm.nih.gov/pubmed/21280127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.568
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