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Structural Differences between Active Forms of Plasminogen Activator Inhibitor Type 1 Revealed by Conformationally Sensitive Ligands

Plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor (serpin) in which the reactive center loop (RCL) spontaneously inserts into a central β-sheet, β-sheet A, resulting in inactive inhibitor. Available x-ray crystallographic studies of PAI-1 in an active conformation relied...

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Bibliografiske detaljer
Main Authors: Li, Shih-Hon, Gorlatova, Natalia V., Lawrence, Daniel A., Schwartz, Bradford S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440609/
https://ncbi.nlm.nih.gov/pubmed/18436534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709455200
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