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NMR determination of pK(a) values in α-synuclein
The intrinsically unfolded protein α-synuclein has an N-terminal domain with seven imperfect KTKEGV sequence repeats and a C-terminal domain with a large proportion of acidic residues. We characterized pK(a) values for all 26 sites in the protein that ionize below pH 7 using 2D (1)H-(15)N HSQC and 3...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048411/ https://ncbi.nlm.nih.gov/pubmed/21280118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.556 |
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