Controlled Extracellular Matrix Degradation in Breast Cancer Tumors Improves Therapy by Trastuzumab

Extracellular matrix (ECM) in solid tumors affects the effectiveness of therapeutics through blocking of intratumoral diffusion and/or physical masking of target receptors on malignant cells. In immunohistochemical studies of tumor sections from breast cancer patients and xenografts, we observed col...

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Hlavní autoři: Beyer, Ines, Li, Zongyi, Persson, Jonas, Liu, Ying, van Rensburg, Ruan, Yumul, Roma, Zhang, Xiao-Bing, Hung, Mien-Chie, Lieber, André
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048180/
https://ncbi.nlm.nih.gov/pubmed/21081901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.256
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