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Tightening of DNA knots by supercoiling facilitates their unknotting by type II DNA topoisomerases
Using numerical simulations, we compare properties of knotted DNA molecules that are either torsionally relaxed or supercoiled. We observe that DNA supercoiling tightens knotted portions of DNA molecules and accentuates the difference in curvature between knotted and unknotted regions. The increased...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048145/ https://ncbi.nlm.nih.gov/pubmed/21321228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016150108 |
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