Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin

The rapid genetic drift of influenza virus hemagglutinin is an obstacle to vaccine efficacy. Previously, we found that the consensus hemagglutinin DNA vaccine (pCHA5) can only elicit moderate neutralization activities toward the H5N1 clade 2.1 and clade 2.3 viruses. Two approaches were thus taken to...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Ming-Wei, Liao, Hsin-Yu, Huang, Yaoxing, Jan, Jia-Tsrong, Huang, Chih-Cheng, Ren, Chien-Tai, Wu, Chung-Yi, Cheng, Ting-Jen Rachel, Ho, David D., Wong, Chi-Huey
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048126/
https://ncbi.nlm.nih.gov/pubmed/21321237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019744108
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