Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin

The rapid genetic drift of influenza virus hemagglutinin is an obstacle to vaccine efficacy. Previously, we found that the consensus hemagglutinin DNA vaccine (pCHA5) can only elicit moderate neutralization activities toward the H5N1 clade 2.1 and clade 2.3 viruses. Two approaches were thus taken to...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chen, Ming-Wei, Liao, Hsin-Yu, Huang, Yaoxing, Jan, Jia-Tsrong, Huang, Chih-Cheng, Ren, Chien-Tai, Wu, Chung-Yi, Cheng, Ting-Jen Rachel, Ho, David D., Wong, Chi-Huey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2011
Aiheet:
Physical Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048126/
https://ncbi.nlm.nih.gov/pubmed/21321237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019744108
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