Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin

The rapid genetic drift of influenza virus hemagglutinin is an obstacle to vaccine efficacy. Previously, we found that the consensus hemagglutinin DNA vaccine (pCHA5) can only elicit moderate neutralization activities toward the H5N1 clade 2.1 and clade 2.3 viruses. Two approaches were thus taken to...

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Detalhes bibliográficos
Main Authors: Chen, Ming-Wei, Liao, Hsin-Yu, Huang, Yaoxing, Jan, Jia-Tsrong, Huang, Chih-Cheng, Ren, Chien-Tai, Wu, Chung-Yi, Cheng, Ting-Jen Rachel, Ho, David D., Wong, Chi-Huey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048126/
https://ncbi.nlm.nih.gov/pubmed/21321237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019744108
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