Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin

The rapid genetic drift of influenza virus hemagglutinin is an obstacle to vaccine efficacy. Previously, we found that the consensus hemagglutinin DNA vaccine (pCHA5) can only elicit moderate neutralization activities toward the H5N1 clade 2.1 and clade 2.3 viruses. Two approaches were thus taken to...

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Autores principales: Chen, Ming-Wei, Liao, Hsin-Yu, Huang, Yaoxing, Jan, Jia-Tsrong, Huang, Chih-Cheng, Ren, Chien-Tai, Wu, Chung-Yi, Cheng, Ting-Jen Rachel, Ho, David D., Wong, Chi-Huey
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Physical Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048126/
https://ncbi.nlm.nih.gov/pubmed/21321237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019744108
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