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Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

Genome-wide erasure of DNA cytosine-5 methylation has been reported to occur along the paternal pronucleus in fertilized oocytes in an apparently replication-independent manner, but the mechanism of this reprogramming process has remained enigmatic. Recently, considerable amounts of 5-hydroxymethylc...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Iqbal, Khursheed, Jin, Seung-Gi, Pfeifer, Gerd P., Szabó, Piroska E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048122/
https://ncbi.nlm.nih.gov/pubmed/21321204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014033108
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