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Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27(Kip1) concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3)
Acute myelogenous leukemia (AML) is a disease characterized by dysregulated cell proliferation associated with impaired cell differentiation, and current treatment regimens rarely save the patient. Thus, new mechanism-based approaches are needed to improve prognosis of this disease. We have investig...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048050/ https://ncbi.nlm.nih.gov/pubmed/21084834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.22.13790 |
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