Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27(Kip1) concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3)

Acute myelogenous leukemia (AML) is a disease characterized by dysregulated cell proliferation associated with impaired cell differentiation, and current treatment regimens rarely save the patient. Thus, new mechanism-based approaches are needed to improve prognosis of this disease. We have investig...

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Main Authors: Wang, Xuening, Gocek, Elzbieta, Novik, Victoria, Harrison, Jonathan S, Danilenko, Michael, Studzinski, George P
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048050/
https://ncbi.nlm.nih.gov/pubmed/21084834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.22.13790
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