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Female infertility in PDE3A(-/-) mice: Polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice
Mechanisms of cAMP/PKA-induced meiotic arrest in oocytes are not completely identified. In cultured, G(2)/M-arrested PDE3A(-/-) murine oocytes, elevated PKA activity was associated with inactivation of Cdc2 and Plk1, and inhibition of phosphorylation of histone H3 (S10) and of dephosphorylation of C...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048038/ https://ncbi.nlm.nih.gov/pubmed/21099356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.23.14090 |
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