Enhanced Neutralization Potency of Botulinum Neurotoxin Antibodies Using a Red Blood Cell-Targeting Fusion Protein

Botulinum neurotoxin (BoNT) potently inhibits cholinergic signaling at the neuromuscular junction. The ideal countermeasures for BoNT exposure are monoclonal antibodies or BoNT antisera, which form BoNT-containing immune complexes that are rapidly cleared from the general circulation. Clearance of o...

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Autors principals: Adekar, Sharad P., Segan, Andrew T., Chen, Cindy, Bermudez, Rodney, Elias, M. D., Selling, Bernard H., Kapadnis, B. P., Simpson, Lance L., Simon, Paul M., Dessain, Scott K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047547/
https://ncbi.nlm.nih.gov/pubmed/21399689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017491
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