Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain

BACKGROUND: Botulinum neurotoxins (BoNT) are a family of category A select bioterror agents and the most potent biological toxins known. Cloned antibody therapeutics hold considerable promise as BoNT therapeutics, but the therapeutic utility of antibodies that bind the BoNT light chain domain (LC),...

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Hauptverfasser: Adekar, Sharad P., Takahashi, Tsuyoshi, Jones, R. Mark, Al-Saleem, Fetweh H., Ancharski, Denise M., Root, Michael J., Kapadnis, B. P., Simpson, Lance L., Dessain, Scott K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2008
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515629/
https://ncbi.nlm.nih.gov/pubmed/18714390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003023
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