Soluble Guanylate Cyclase α1β1 Limits Stroke Size and Attenuates Neurological Injury

BACKGROUND AND PURPOSE: Nitric oxide (NO) mediates endothelium-dependent vasodilation, modulates cerebral blood flow (CBF), and determines stroke outcome. NO signals in part by stimulating soluble guanylate cyclase (sGC) to synthesize cGMP. To study the role of sGC in stroke injury, we compared the...

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Detalhes bibliográficos
Main Authors: Atochin, Dmitriy N., Yuzawa, Izumi, Li, Qian, Rauwerdink, Kristen M., Malhotra, Rajeev, Chang, Junlei, Brouckaert, Peter, Ayata, Cenk, Moskowitz, Michael A., Bloch, Kenneth D., Huang, Paul L., Buys, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047459/
https://ncbi.nlm.nih.gov/pubmed/20595671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.109.577635
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