Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice

Nitric oxide (NO) plays an essential role in regulating hypertension and blood flow by inducing relaxation of vascular smooth muscle. Male mice deficient in a NO receptor component, the α1 subunit of soluble guanylate cyclase (sGCα(1)), are prone to hypertension in some, but not all, mouse strains,...

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Detalhes bibliográficos
Main Authors: Buys, Emmanuel S., Raher, Michael J., Kirby, Andrew, Mohd, Shahid, Baron, David M., Hayton, Sarah R., Tainsh, Laurel T., Sips, Patrick Y., Rauwerdink, Kristen M., Yan, Qingshang, Tainsh, Robert E.T., Shakartzi, Hannah R., Stevens, Christine, Decaluwé, Kelly, Rodrigues-Machado, Maria da Gloria, Malhotra, Rajeev, Van de Voorde, Johan, Wang, Tong, Brouckaert, Peter, Daly, Mark J., Bloch, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366402/
https://ncbi.nlm.nih.gov/pubmed/22565307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60119
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