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Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis.

Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective...

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Detaylı Bibliyografya
Asıl Yazarlar: Ishikawa, Tomo-o, Oshima, Masanobu, Herschman, Harvey R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047239/
https://ncbi.nlm.nih.gov/pubmed/21156970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq268
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