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Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression

Cyclooxygenase-2 (COX-2), a key enzyme of prostanoid biosynthesis, plays an important role in both hereditary and spontaneous colon cancer. Individuals with ulcerative colitis are also at high risk for colorectal cancer. To investigate the role of Cox-2 in colitis-associated colon cancer, we subject...

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Detalhes bibliográficos
Main Authors: Ishikawa, Tomo-o, Herschman, Harvey R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847091/
https://ncbi.nlm.nih.gov/pubmed/20061361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq002
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