Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers

OBJECTIVE: Topotecan, a novel topoisomerase-1 inhibitor, is a drug that appears to be effective against platinum-resistant ovarian cancers. However, the molecular mechanisms by which Topotecan treatment inhibits cancer cell proliferation are unclear. We investigated whether Topotecan increases the e...

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Bibliografiske detaljer
Main Authors: Tsunetoh, Satoshi, Terai, Yoshito, Sasaki, Hiroshi, Tanabe, Akiko, Tanaka, Yoshimichi, Sekijima, Tatsuharu, Fujiwara, Satoe, Kawaguchi, Hiroshi, Kanemura, Masanori, Yamashita, Yoshiki, Ohmichi, Masahide
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047105/
https://ncbi.nlm.nih.gov/pubmed/20935474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.11.13443
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