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Ca(2+)-Dependent Phosphorylation of RyR2 Can Uncouple Channel Gating from Direct Cytosolic Ca(2+) Regulation
Phosphorylation of the cardiac ryanodine receptor (RyR2) is thought to be important not only for normal cardiac excitation-contraction coupling but also in exacerbating abnormalities in Ca(2+) homeostasis in heart failure. Linking phosphorylation to specific changes in the single-channel function of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047053/ https://ncbi.nlm.nih.gov/pubmed/21274522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-011-9339-9 |
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