Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

OBJECTIVE: We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both β-cell mass and function. RESEARCH DESIGN AND METHODS: Mice with β-cell–specific deletions of Ricto...

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Detalles Bibliográficos
Main Authors: Gu, Yanyun, Lindner, Jill, Kumar, Anil, Yuan, Weiping, Magnuson, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2011
Assuntos:
Islet Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046843/
https://ncbi.nlm.nih.gov/pubmed/21266327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1194
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